The bilirubin can either be unconjugated indirect bilirubin or conjugated direct bilirubin. Differential diagnosis jaundice can be caused by a malfunction in any of the three phases of bilirubin production tables 1 and 2. Jaundice may not be clinically evident until serum levels 3 mgdl. Differential diagnosis of icterusjaundice slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. What is the differential diagnosis of neonatal unconjugated. An initial approach to the workup of any liver disease is to determine the acuteness of symptoms. Evaluating jaundice radiologic evaluation confirmation of clinically suspected biliary obstruction by demonstrating intrahepatic andor extrahepatic duct dilation identification of site and cause of the obstruction selection of the appropriate treatment modality for managing the jaundice. The treatment of jaundice in adults and elderly subjects is amongst the themes selected for elaborating the crps since jaundice is a medical sign frequently seen in four clinical scenarios involving distinctive diagnostic and therapeutic interventions which can be performed in different health care settings. For the differential diagnosis for jaundice and ruq pain, click here. Assessment of jaundice differentials bmj best practice.
Bilirubin is a break down product of haemoglobin, manufactured by the reticuloendothelial system mainly in the spleen and bonemarrow but also in any other organs or tissues of the body where. Further blood tests may be needed if your babys jaundice lasts. In prehepatic jaundice, there is excess production of bilirubin that overtakes the ability of liver to conjugate the. Other symptoms may include excess sleepiness or poor feeding.
She had been breastfeeding well, with several stools and many voids. Pdf jaundice is not a disease but rather a sign that can occur in many different diseases. To be updated when it is complete please like us on facebook, follow us on twitter. Neonatal jaundice is the condition of elevated bilirubin at the time of birth. Jaundice is a condition in which yellow discoloration of the skin and mucous membranes occur due to an increase in the bile pigments, namely, bilirubin in the blood. Babies who are breast fed may also have prolonged jaundice for up to 4 weeks or more, for reasons that are not completely understood.
Jaundice is a sign in several diseases due to viruses viral hepatitis and arbovirus, parasites malaria and bacteria leptospirosis. Bilirubin is a yellowish pigment present in hemoglobin responsible for carrying oxygen in red blood cells. A systematic approach to patients with jaundice request pdf. Jaundice becomes clinically evident when serum bilirubin level exceeds 2. Jaundice yellow discoloration of skin, sclera, and mucous membranes due to increased level of serum bilirubin. Started in 1995, this collection now contains 6769 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters.
A systematic approach to patients with jaundice article in seminars in interventional radiology 3304. Jaundice icterus is the result of accumulation of bilirubin in the bloodstream and subsequent deposition in the skin, sclera, and mucous membranes. It is in these cases that a diagnosis is often made by clinical experience and keen observation together with laboratory evidence. Nonalcoholic fatty liver disease nafld parenchymal liver disease common in patients with the metabolic syndrome phenotype is obese diabetic with hyperlipidemia but can also occur in obese patients without other comorbidities. Guideline for the evaluation of cholestatic jaundice. Mean peak total serum bilirubin is 6 mgdl higher in asian infants. Obstructive pattern along with only modest elevation of liver enzymes suggests the. An increase in the concentration of bilirubin above 3 mg per dl of blood causes neonatal jaundice. With a focused history and physical exam, an accurate diagnosis is possible in approximately 85% of patients. Viral hepatitis is the one of the most common causes of acute onset of jaundice. Jaundice is yellowish discoloration of the skin, conjunctiva, and mucous membranes caused by hyperbilirubinemia. Neonatal jaundice background the term jaundice comes from the root jaune, the french word for yellow.
Evaluation of jaundice differential diagnosis of symptoms. Jaundice is a symptom of an underlying condition rather than a disease in itself. Meinertlimitations and merits of a single serum sample analysis in the differential diagnosis of jaundice. Get a printable copy pdf file of the complete article 885k, or click on a page image below to browse page by page. Strategies for generating differential diagnoses a number of different strategies can be used to generate a differential diagnosis. Jaundice in adults can be an indicator of significant underlying disease. Nonneonatal jaundice background jaundice is a yellowish discolouration of the skin, sclera, and mucous membranes due to elevated bilirubin as result of abnormal bilirubin metabolism andor excretion. Jaundice in adult inpatients at a tertiary general hospital. Jaundice is common in the neonatal period, affecting 5060% of newborns. Since it is known that an obstructive jaundice which persists for six weeks will be complicated by liver cell degeneration, surgery may finally be necessary in order to determine the cause of the jaundice. Blood tests are usually only necessary if your baby developed jaundice within 24 hours of birth or the reading is particularly high.
He denies nv, abdominal pain, po intolerance, fc, recent travel, weight loss. The differential diagnosis of jaundice sciencedirect. Intestinal bacteria convert some of the extra bilirubin into urobilinogen, some of which is reabsorbed and is excreted. Jaundice develops from hyperbilirubinemiaand may not be noticed until the bilirubinexceeds 50 umoll. He states that this has not occurred in the past, and he. Jaundice in the newborns jaundice is the most common morbidity in the first week of life, occurring in 60% of term and 80% of preterm newborn. Obstructive jaundice caused by biliary tuberculosis. At those times adding a different strategy often reveals more conditions. To be updated when it is complete please like us on facebook, follow us on twitter or subscribe on youtube using the follow us b. To be updated when it is complete please like us on facebook, follow us on twitter or subscribe on youtube using the follow us buttons. Jaundice occurs in all age groups but is much more common in neonates and infants. Jaundice is commonly encountered in patients in intensive care unit, with high incidence as 40%, and high mortality 5. Varughese george laboratory diagnosis of jaundice by dr. Certain strategies work better for different symptoms.
A patient presenting with jaundice is a diagnostic challenge and the causes include a broad spectrum of diseases from very benign conditions to the most malignant. However this is a diagnosis of exclusion and it should not be automatically accepted that breast milk is the cause of a babys prolonged jaundice. Apr 21, 2008 patient presentation a 3dayold female came to clinic with jaundice. History taking and physical examination for the patient with liver disease. The following terminology is important to know when diagnosing jaundice. Obstruction jaundice an obstruction in the bile ducts or digestive area. Aknowledge of the natural history of bili rubinis essential fortheclear differentiation ofthe different types ofjaundice.
Jaundice in newborn babies sydney childrens hospital. The differential diagnosis of intra and extrahepatic. The differential diagnosis of cholestatic jaundice in the older child differs from diseases that present early in life. The causes of jaundice and asymptomatic hyperbilirubinemia, detailed discussions of the specific testing used, and the evaluation of patients with other liver test abnormalities are discussed elsewhere. Jaundice is caused by an accumulation of a yellowgreen substance called bilirubin in the tissues of the body. Feb 22, 2014 differential diagnosis of icterusjaundice slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website. National healthy mothers, healthy babies coalition.
Differential diagnosis of obstructive jaundice springerlink. Jaundice consisting of either direct or indirect bilirubin, that is present at birth or appears with in the first 24 hours of life causes. Yellowgreen in appearance in chronic, severe obstructive jaundice biliverdin. Of note, current differential diagnostic plans now incorporate. Erythroblastosis fetalis high direct bilirubin in infants who were given intrauterine transfusions. She was a 39 week infant born by spontaneous vaginal delivery without complications who was discharged on day 2 of life with a transcutaneous bilirubin of 10. The differential diagnosis in older children and adolescents however, is very different from infants and neonates and thus will be explored here. Biliaryobstruction gives a greenish skin tint due to accumulation of biliverdin. Tests, imaging, differential diagnosis learning objectives. This was associated with dark urine and loose, lightbrown stools.
Singlesample tests in the differential diagnosis of jaundice. In these infants, a baseline physiologic jaundice most likely occurs, which is then exaggerated, for example, by increased enterohepatic circulation in bowel atresia, bile stasis in choledochal cyst, or increased bilirubin production in hemolytic anemias. At the 20 noviembre issste hospital in mexico city, between january 1977 and may 1984, data were. Full text full text is available as a scanned copy of the original print version.
Differential dx strategies university of massachusetts. Hepatocellular jaundice when the liver fails to process bilirubin. Jaundice can occur in babies, children, and adults find, read and. Diagnosis of pbc patients with pbc may present with symptoms as fatigue, pruritus andor jaundice, but the majority of them are asymptomatic at diagnosis. Laboratory diagnosis of jaundice linkedin slideshare. Clinical and regulatory protocol for the treatment of. Bilirubin is a yellow chemical in hemoglobin, the substance that carries oxygen in your red blood cells. Although the presence of jaundice suggests pathology, it is nonspecific. Neonatal jaundice is a yellowish discoloration of the white part of the eyes and skin in a newborn baby due to high bilirubin levels. The treatment of jaundice in adults and elderly subjects is amongst the themes selected for elaborating the crps since jaundice is a medical sign frequently seen in four clinical scenarios involving distinctive diagnostic and therapeutic interventions which.
The level of bilirubin detected in your babys blood is used to decide whether any treatment is needed. Jaundice introduction approximately 60% of term babies and 85% of preterm babies will develop clinically apparent jaundice. Extrahepatic obstructive jaundice is an indication for surgical treatment, except perhaps in cases of sclerosing cholangitis. Patient presentation a 3dayold female came to clinic with jaundice. Differential diagnosis differentialdiagnosis oficterus.
Presentation of jaundice pathophysiology of jaundice pre hepatic o increased breakdown of red cells leads to increased serum bilirubin. Jaundice is a yellow discoloration of body tissues due to an excess of bilirubin. Full text get a printable copy pdf file of the complete article 5. Identification of pathogens for differential diagnosis of fever with. It is caused by elevated serum bilirubin levels in the unconjugated or conjugated form. Total serum bilirubin peaks at age 35 d later in asian infants. Medications are another common causes of acute liver injury. Neonatal jaundice can affect up to 84% of term newborns and is often a benign process that is quickly corrected once identified. Get a printable copy pdf file of the complete article 686k, or click on a page image below. Newborns should be checked for jaundice before leaving the hospital and again within 48 hours after hospital discharge. Jaundice causes your skin and the whites of your eyes to turn yellow. The diagnosis of pbc is based on a combination of findings, including cholestatic liver enzyme levels, positive antimitochondrial antibody ama, and characteristic liver biopsy findings. Usually, the concentration of bilirubin in the blood must exceed 23 mgdl for the coloration to be easily visible. The differential diagnosis between intra and extrahepatic causes of jaundice was studied.
Dec 27, 2017 certain conditions may cause nonphysiologic jaundice. In most cases, a bilirubinometer is used to check for jaundice in babies. Presentation of jaundice pathophysiology of jaundice. Jaundice may not be clinically evident until serum levels 51 mi. As red blood cells break down, your body builds new cells to replace them.
Jaundice is the number one reason babies are readmitted to the hospital. Check for signs of the underlying chronic liver disease. Hemolytic jaundice from red blood cells being broken down. This unconjugated bilirubin isnt watersoluble so cant be excreted in the urine. If gallbladder palpable, then stone disease unlikely courvoisiers law splenomegaly is suggestive of cirrhosis, haematological disorders or reticulosis differential diagnosis. After generating a differential, you may decide that you would like to expand upon it. Neonatal jaundice occurring in newborns a few days after birth. This topic will provide an overview of the diagnostic approach to adults with jaundice or asymptomatic hyperbilirubinemia. In patients with trauma, the cause of jaundice was bilirubin over. Neonatal jaundice physiologic jaundice nonpathologic unconjugated hyperbilirubinemia.
The causes of jaundice and asymptomatic hyperbilirubinemia, detailed discussions of the specific testing used, and the evaluation of patients with other liver. Scleralelastinhas a high affinity for bilirubin, and with a white background, it is a sensitive indicator of jaundice. Jaundice symptoms, diagnosis, treatments and causes. Common and important causes of jaundice for doctors and medical students this page is currently being written and will be available soon. The following are statistics from various sources about hospitalizations and neonatal jaundice. Differential diagnosis for jaundice oxford medical education.
80 1001 760 884 220 194 963 1313 1022 1121 109 1567 954 442 1336 1255 411 894 736 1150 268 940 116 226 795 1275 48 427 409 559 500 842 807 397 1202 994 1227 313 676 224 1438 1123 1291 1117